Intradiscal Injection of Chondroitinase ABC in Down Dogs with IVDD with Dr. Nicholas Jeffery

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August 2025

In today’s VETgirl online veterinary continuing education podcast, we interview Dr. Nick Jeffery, BVSc, PhD, MSc, DECVS, DECVN, Professor in Neurology and Neurosurgery from Texas A&M on a recent study by Freeman et al entitled “Percutaneous enzymatic chemonucleolysis of intervertebral disks appears safe and effective in treatment of acute-onset paraparesis and paraplegia in small dogs,” published in JAVMA in March 2025. Can the use of intradiscal chondroitinase ABC (often called “CHASE”) injections under fluoroscopic-guidance work as a safe, minimally invasive option for small dogs with acute nonambulatory paraparesis or paraplegia, especially when deep pain perception is intact? If you’re a general practitioner who sees a lot of down dogs—and especially if you practice in a Dachshund-heavy region—you’ll definitely want to tune in.

Reference:
1. Freeman P, Atiee G, Donoghue EM, Jeffery ND. Percutaneous enzymatic chemonucleolysis of intervertebral disks appears safe and effective in treatment of acute-onset paraparesis and paraplegia in small dogs. J Am Vet Med Assoc 2025; doi.org/10.2460/javma.24.12.0790.

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